Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships.

Polucci, Paolo; Magnaghi, Paola; Angiolini, Mauro; Asa, Daniela; Avanzi, Nilla; Badari, Alessandra; Bertrand, Jay; Casale, Elena; Cauteruccio, Silvia; Cirla, Alessandra; Cozzi, Liviana; Galvani, Arturo; Jackson, Peter K; Liu, Yichin; Magnuson, Steven; Malgesini, Beatrice; Nuvoloni, Stefano; Orrenius, Christian; Sirtori, Federico Riccardi; Riceputi, Laura; Rizzi, Simona; Trucchi, Beatrice; O'Brien, Tom; Isacchi, Antonella; Donati, Daniele; D'Alessio, Roberto

Polucci, Paolo; Magnaghi, Paola; Angiolini, Mauro; Asa, Daniela; Avanzi, Nilla; Badari, Alessandra; Bertrand, Jay; Casale, Elena; Cauteruccio, Silvia; Cirla, Alessandra; Cozzi, Liviana; Galvani, Arturo; Jackson, Peter K; Liu, Yichin; Magnuson, Steven; Malgesini, Beatrice; Nuvoloni, Stefano; Orrenius, Christian; Sirtori, Federico Riccardi; Riceputi, Laura; Rizzi, Simona; Trucchi, Beatrice; O'Brien, Tom; Isacchi, Antonella; Donati, Daniele; D'Alessio, Roberto.

Affiliation

Polucci P; Nerviano Medical Sciences S.r.l., Oncology, Viale Pasteur 10, 20014 Nerviano (MI), Italy.

J Med Chem ; 56(2): 437-50, 2013 Jan 24.

Article in En | MEDLINE | ID: mdl-23245311

Subject(s)

Adenosine Triphosphatases/antagonists & inhibitors; Cell Cycle Proteins/antagonists & inhibitors; Triazoles/pharmacology; Adenosine Triphosphatases/chemistry; Allosteric Regulation; Cell Cycle Proteins/chemistry; Humans; Neoplasms/pathology; Structure-Activity Relationship; Triazoles/chemical synthesis; Triazoles/chemistry; Valosin Containing Protein

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triazoles / Adenosine Triphosphatases / Cell Cycle Proteins Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2013 Type: Article Affiliation country: Italy

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