Focal Scn1a knockdown induces cognitive impairment without seizures.

Bender, Alex C; Natola, Heather; Ndong, Christian; Holmes, Gregory L; Scott, Rod C; Lenck-Santini, Pierre-Pascal

Bender, Alex C; Natola, Heather; Ndong, Christian; Holmes, Gregory L; Scott, Rod C; Lenck-Santini, Pierre-Pascal.

Affiliation

Bender AC; Department of Neurology, Neuroscience Center at Dartmouth, Geisel School of Medicine at Dartmouth, Hanover, NH03756,USA.

Neurobiol Dis ; 54: 297-307, 2013 Jun.

Article in En | MEDLINE | ID: mdl-23318929

Subject(s)

Cognition Disorders/metabolism; Cognition Disorders/physiopathology; Epilepsies, Myoclonic/metabolism; NAV1.1 Voltage-Gated Sodium Channel/biosynthesis; Animals; Blotting, Western; Cognition Disorders/genetics; Electroencephalography; Epilepsies, Myoclonic/complications; Epilepsies, Myoclonic/genetics; Gene Knockdown Techniques; Immunohistochemistry; Male; NAV1.1 Voltage-Gated Sodium Channel/genetics; RNA, Small Interfering; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Seizures/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Epilepsies, Myoclonic / Cognition Disorders / NAV1.1 Voltage-Gated Sodium Channel Limits: Animals Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2013 Type: Article Affiliation country: United States

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