Nucleophosmin mutations alter its nucleolar localization by impairing G-quadruplex binding at ribosomal DNA.

Chiarella, Sara; De Cola, Antonella; Scaglione, Giovanni Luca; Carletti, Erminia; Graziano, Vincenzo; Barcaroli, Daniela; Lo Sterzo, Carlo; Di Matteo, Adele; Di Ilio, Carmine; Falini, Brunangelo; Arcovito, Alessandro; De Laurenzi, Vincenzo; Federici, Luca

Chiarella, Sara; De Cola, Antonella; Scaglione, Giovanni Luca; Carletti, Erminia; Graziano, Vincenzo; Barcaroli, Daniela; Lo Sterzo, Carlo; Di Matteo, Adele; Di Ilio, Carmine; Falini, Brunangelo; Arcovito, Alessandro; De Laurenzi, Vincenzo; Federici, Luca.

Affiliation

Chiarella S; Department of Biochemical Sciences, 'Sapienza' University of Rome, 00185 Rome, Italy.

Nucleic Acids Res ; 41(5): 3228-39, 2013 Mar 01.

Article in En | MEDLINE | ID: mdl-23328624

Subject(s)

Cell Nucleolus/metabolism; DNA, Ribosomal/genetics; G-Quadruplexes; Nuclear Proteins/genetics; Amino Acid Sequence; Amino Acid Substitution; Base Sequence; Binding, Competitive; Cell Line; Cell Survival/drug effects; DNA, Ribosomal/chemistry; DNA, Ribosomal/metabolism; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Proteins/chemistry; Nuclear Proteins/metabolism; Nucleophosmin; Oligonucleotides/chemistry; Porphyrins/chemistry; Porphyrins/pharmacology; Protein Binding; Protein Structure, Tertiary; Protein Transport

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA, Ribosomal / Nuclear Proteins / Cell Nucleolus / G-Quadruplexes Limits: Humans Language: En Journal: Nucleic Acids Res Year: 2013 Type: Article Affiliation country: Italy

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