Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.

Deshpande, Aniruddha J; Chen, Liying; Fazio, Maurizio; Sinha, Amit U; Bernt, Kathrin M; Banka, Deepti; Dias, Stuart; Chang, Jenny; Olhava, Edward J; Daigle, Scott R; Richon, Victoria M; Pollock, Roy M; Armstrong, Scott A

Deshpande, Aniruddha J; Chen, Liying; Fazio, Maurizio; Sinha, Amit U; Bernt, Kathrin M; Banka, Deepti; Dias, Stuart; Chang, Jenny; Olhava, Edward J; Daigle, Scott R; Richon, Victoria M; Pollock, Roy M; Armstrong, Scott A.

Affiliation

Deshpande AJ; Division of Hematology/Oncology, Children's Hospital, Boston, MA, USA.

Blood ; 121(13): 2533-41, 2013 Mar 28.

Article in En | MEDLINE | ID: mdl-23361907

Subject(s)

Cell Transformation, Neoplastic/genetics; Histone-Lysine N-Methyltransferase/genetics; Kinesins/genetics; Methyltransferases/physiology; Myeloid-Lymphoid Leukemia Protein/genetics; Myosins/genetics; Oncogene Proteins, Fusion/genetics; Adenosine/analogs & derivatives; Adenosine/pharmacology; Animals; Cell Proliferation/drug effects; Cell Transformation, Neoplastic/drug effects; Cell Transformation, Neoplastic/metabolism; Cells, Cultured; Enzyme Inhibitors/pharmacology; Histone Methyltransferases; Histone-Lysine N-Methyltransferase/metabolism; Histone-Lysine N-Methyltransferase/physiology; Lysine/metabolism; Methyltransferases/antagonists & inhibitors; Methyltransferases/genetics; Methyltransferases/metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Phenylurea Compounds/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oncogene Proteins, Fusion / Cell Transformation, Neoplastic / Histone-Lysine N-Methyltransferase / Myosins / Kinesins / Myeloid-Lymphoid Leukemia Protein / Methyltransferases Limits: Animals Language: En Journal: Blood Year: 2013 Type: Article Affiliation country: United States

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