Estrogen receptor &#945; mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor ß.

Galea, Gabriel L; Meakin, Lee B; Sugiyama, Toshihiro; Zebda, Noureddine; Sunters, Andrew; Taipaleenmaki, Hanna; Stein, Gary S; van Wijnen, Andre J; Lanyon, Lance E; Price, Joanna S

Estrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor ß.

Galea, Gabriel L; Meakin, Lee B; Sugiyama, Toshihiro; Zebda, Noureddine; Sunters, Andrew; Taipaleenmaki, Hanna; Stein, Gary S; van Wijnen, Andre J; Lanyon, Lance E; Price, Joanna S.

Affiliation

Galea GL; School of Veterinary Sciences, University of Bristol, Bristol BS40 5DU, United Kingdom. gabriel.galea@bristol.ac.uk

J Biol Chem ; 288(13): 9035-48, 2013 Mar 29.

Article in En | MEDLINE | ID: mdl-23362266

Subject(s)

Bone Morphogenetic Proteins/metabolism; Estrogen Receptor alpha/metabolism; Estrogen Receptor beta/metabolism; Estrogens/metabolism; Glycoproteins/metabolism; Osteoblasts/metabolism; Adaptor Proteins, Signal Transducing; Animals; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Estradiol/metabolism; Female; Genetic Markers; Humans; Intercellular Signaling Peptides and Proteins; Ki-67 Antigen/biosynthesis; Ligands; Mice; Models, Biological; Protein Binding; Stress, Mechanical; Tamoxifen/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoblasts / Glycoproteins / Bone Morphogenetic Proteins / Estrogen Receptor alpha / Estrogen Receptor beta / Estrogens Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: J Biol Chem Year: 2013 Type: Article Affiliation country: United kingdom

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