Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin/lysophosphatidic acid axis.

Bai, Zhongbin; Cai, Linjun; Umemoto, Eiji; Takeda, Akira; Tohya, Kazuo; Komai, Yutaka; Veeraveedu, Punniyakoti Thanikachalam; Hata, Erina; Sugiura, Yuki; Kubo, Akiko; Suematsu, Makoto; Hayasaka, Haruko; Okudaira, Shinichi; Aoki, Junken; Tanaka, Toshiyuki; Albers, Harald M H G; Ovaa, Huib; Miyasaka, Masayuki

Bai, Zhongbin; Cai, Linjun; Umemoto, Eiji; Takeda, Akira; Tohya, Kazuo; Komai, Yutaka; Veeraveedu, Punniyakoti Thanikachalam; Hata, Erina; Sugiura, Yuki; Kubo, Akiko; Suematsu, Makoto; Hayasaka, Haruko; Okudaira, Shinichi; Aoki, Junken; Tanaka, Toshiyuki; Albers, Harald M H G; Ovaa, Huib; Miyasaka, Masayuki.

Affiliation

Bai Z; Laboratory of Immunodynamics, World Premier International Research Center Initiative-Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan.

J Immunol ; 190(5): 2036-48, 2013 Mar 01.

Article in En | MEDLINE | ID: mdl-23365076

Subject(s)

Basement Membrane/drug effects; Endothelium/drug effects; Lymphocytes/drug effects; Lysophosphatidylcholines/pharmacology; Lysophospholipids/pharmacology; Phosphoric Diester Hydrolases/genetics; Venules/drug effects; Animals; Basement Membrane/metabolism; Endothelium/metabolism; Enzyme Inhibitors/pharmacology; Female; Gene Expression/drug effects; Lymph Nodes/cytology; Lymph Nodes/drug effects; Lymph Nodes/metabolism; Lymphocytes/cytology; Lymphocytes/metabolism; Lysophosphatidylcholines/metabolism; Lysophospholipids/metabolism; Mice; Mice, Inbred C57BL; Myosin Type II/genetics; Myosin Type II/metabolism; Phosphoric Diester Hydrolases/metabolism; Receptors, Lysophosphatidic Acid/antagonists & inhibitors; Receptors, Lysophosphatidic Acid/genetics; Receptors, Lysophosphatidic Acid/metabolism; Signal Transduction/drug effects; Spleen/cytology; Spleen/drug effects; Spleen/metabolism; Transendothelial and Transepithelial Migration/drug effects; Venules/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Basement Membrane / Venules / Lysophospholipids / Lymphocytes / Lysophosphatidylcholines / Phosphoric Diester Hydrolases / Endothelium Limits: Animals Language: En Journal: J Immunol Year: 2013 Type: Article Affiliation country: Japan

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