In vivo and ex vivo inhibition of spinal nerve ligation-induced ectopic activity by sodium channel blockers correlate to in vitro inhibition of NaV1.7 and clinical efficacy: a pharmacokinetic-pharmacodynamic translational approach.

Kalezic, Ivana; Luo, Lei; Lund, Per-Eric; Eriksson, Anders B; Bueters, Tjerk; Visser, Sandra A G

Kalezic, Ivana; Luo, Lei; Lund, Per-Eric; Eriksson, Anders B; Bueters, Tjerk; Visser, Sandra A G.

Affiliation

Kalezic I; Neuroscience, CNSP Innovative Medicines, AstraZeneca R&D, S-151 85, Södertälje, Sweden.

Pharm Res ; 30(5): 1409-22, 2013 May.

Article in En | MEDLINE | ID: mdl-23371514

Subject(s)

NAV1.7 Voltage-Gated Sodium Channel/metabolism; Neuralgia/drug therapy; Sodium Channel Blockers/blood; Sodium Channel Blockers/pharmacology; Spinal Nerves/drug effects; Animals; HEK293 Cells; Humans; Ligation; Male; Rats; Rats, Sprague-Dawley; Spinal Nerves/surgery

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinal Nerves / Sodium Channel Blockers / NAV1.7 Voltage-Gated Sodium Channel / Neuralgia Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Pharm Res Year: 2013 Type: Article Affiliation country: Sweden

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