The role of telomeres in stem cells and cancer.
Cell
; 152(3): 390-3, 2013 Jan 31.
Article
in En
| MEDLINE
| ID: mdl-23374336
ABSTRACT
Telomere shortening impairs proliferation of transformed cells but also leads to cancer initiation by inducing chromosomal instability. Here, we discuss recent developments in our understanding of the role of telomeres in replication stress and how telomerase expression in somatic stem cells may affect genome integrity control and carcinogenesis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stem Cells
/
Telomere
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Cell
Year:
2013
Type:
Article
Affiliation country:
Germany