Selective elimination of malaria infected erythrocytes by a modified phospholipase A2 in vitro.
Biochim Biophys Acta
; 1024(1): 189-92, 1990 May 09.
Article
in En
| MEDLINE
| ID: mdl-2337614
ABSTRACT
Pig pancreatic phospholipase A2 does not act on normal erythrocytes, but the membrane penetrating capacity is enhanced by the covalent attachment of one fatty acyl chain to Lys-116 of the enzyme. Taking advantage of the impaired packing of phospholipids in the membrane of Plasmodium infected erythrocytes it was demonstrated that a lauric acid derivative of phospholipase A2 is capable of exclusively attaching the infected erythrocytes in vitro, leaving the uninfected cells undisturbed. The chemically modified phospholipase A2 appeared to cause death of the parasite in cell cultures of infected erythrocytes.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phospholipases
/
Phospholipases A
/
Erythrocytes
/
Malaria
Limits:
Animals
Language:
En
Journal:
Biochim Biophys Acta
Year:
1990
Type:
Article
Affiliation country:
Netherlands