Preclinical therapy of disseminated HER-2âº ovarian and breast carcinomas with a HER-2-retargeted oncolytic herpesvirus.

Nanni, Patrizia; Gatta, Valentina; Menotti, Laura; De Giovanni, Carla; Ianzano, Marianna; Palladini, Arianna; Grosso, Valentina; Dall'ora, Massimiliano; Croci, Stefania; Nicoletti, Giordano; Landuzzi, Lorena; Iezzi, Manuela; Campadelli-Fiume, Gabriella; Lollini, Pier-Luigi

Preclinical therapy of disseminated HER-2âº ovarian and breast carcinomas with a HER-2-retargeted oncolytic herpesvirus.

Nanni, Patrizia; Gatta, Valentina; Menotti, Laura; De Giovanni, Carla; Ianzano, Marianna; Palladini, Arianna; Grosso, Valentina; Dall'ora, Massimiliano; Croci, Stefania; Nicoletti, Giordano; Landuzzi, Lorena; Iezzi, Manuela; Campadelli-Fiume, Gabriella; Lollini, Pier-Luigi.

Affiliation

Nanni P; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

PLoS Pathog ; 9(1): e1003155, 2013 Jan.

Article in En | MEDLINE | ID: mdl-23382683

Subject(s)

Breast Neoplasms/therapy; Herpesvirus 1, Human/genetics; Oncolytic Virotherapy/methods; Oncolytic Viruses/genetics; Ovarian Neoplasms/therapy; Peritoneal Neoplasms/therapy; Animals; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/metabolism; Breast Neoplasms/metabolism; Breast Neoplasms/mortality; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Genetic Therapy/methods; Genetic Vectors/genetics; Genetic Vectors/metabolism; Herpesvirus 1, Human/physiology; Humans; Mice; Mice, Nude; Molecular Targeted Therapy; Oncolytic Viruses/metabolism; Ovarian Neoplasms/metabolism; Ovarian Neoplasms/mortality; Peritoneal Neoplasms/mortality; Peritoneal Neoplasms/secondary; Receptor, ErbB-2/genetics; Receptor, ErbB-2/metabolism; Survival Rate; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Peritoneal Neoplasms / Breast Neoplasms / Herpesvirus 1, Human / Oncolytic Viruses / Oncolytic Virotherapy Limits: Animals / Female / Humans Language: En Journal: PLoS Pathog Year: 2013 Type: Article Affiliation country: Italy

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