Your browser doesn't support javascript.
loading
Temporal pattern of cytotoxic edema in the perihematomal region after intracerebral hemorrhage: a serial magnetic resonance imaging study.
Li, Na; Worthmann, Hans; Heeren, Meike; Schuppner, Ramona; Deb, Milani; Tryc, Anita B; Bueltmann, Eva; Lanfermann, Heinrich; Donnerstag, Frank; Weissenborn, Karin; Raab, Peter.
Affiliation
  • Li N; Department of Neurology, Hannover Medical School, Hannover, Germany. selina1808@gmail.com
Stroke ; 44(4): 1144-6, 2013 Apr.
Article in En | MEDLINE | ID: mdl-23391767
BACKGROUND AND PURPOSE: Knowledge about cytotoxic edema (CE) in intracerebral hemorrhage is still limited. We aimed to analyze its presence, temporal pattern, and prognostic meaning. METHODS: Twenty-one patients with primary intracerebral hemorrhage underwent magnetic resonance imaging at days 1, 3, and 7 after symptom onset. CE was identified using diffusion-weighted imaging. Hematoma and perihematomal edema volumes were measured on fluid-attenuated inversion recovery images. National Institutes of Health Stroke Scale score was assessed at admission and with each magnetic resonance imaging. Clinical outcome was assessed by modified Rankin scale at 90 days. RESULTS: CE appeared in half of the patients within the first 24 hours. The apparent diffusion coefficient values decreased until day 3 and were significantly reversed from days 3 through 7 (P<0.01). Patients with CE showed significantly faster perihematomal edema growth from day 0 to 1 (P=0.036) than those without. Larger 3-day perihematomal edema volume (P=0.02) and presence of CE on day 3 (P=0.07) were associated with poor clinical outcome. CONCLUSIONS: CE is associated with stroke severity, perihematomal edema volume, and poor outcome. It is considered to indicate ongoing neuronal injury and, thus, might emerge as new treatment target.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Edema / Magnetic Resonance Imaging / Cerebral Hemorrhage Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Stroke Year: 2013 Type: Article Affiliation country: Germany

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Edema / Magnetic Resonance Imaging / Cerebral Hemorrhage Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Stroke Year: 2013 Type: Article Affiliation country: Germany