Genetic modulation of islet ß-cell iPLA2ß expression provides evidence for its impact on ß-cell apoptosis and autophagy.

Lei, Xiaoyong; Bone, Robert N; Ali, Tomader; Wohltmann, Mary; Gai, Ying; Goodwin, Karen J; Bohrer, Alan E; Turk, John; Ramanadham, Sasanka

Lei, Xiaoyong; Bone, Robert N; Ali, Tomader; Wohltmann, Mary; Gai, Ying; Goodwin, Karen J; Bohrer, Alan E; Turk, John; Ramanadham, Sasanka.

Affiliation

Lei X; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

Islets ; 5(1): 29-44, 2013.

Article in En | MEDLINE | ID: mdl-23411472

Subject(s)

Apoptosis; Autophagy; Endoplasmic Reticulum Stress; Gene Expression Regulation, Enzymologic; Group IV Phospholipases A2/metabolism; Insulin-Secreting Cells/metabolism; Animals; Apoptosis/drug effects; Autophagy/drug effects; Caspase 3/metabolism; Ceramides/metabolism; Diabetes Mellitus/enzymology; Diabetes Mellitus/metabolism; Endoplasmic Reticulum Stress/drug effects; Enzyme Activation/drug effects; Enzyme Inhibitors/pharmacology; Gene Expression Regulation, Enzymologic/drug effects; Group IV Phospholipases A2/biosynthesis; Group IV Phospholipases A2/genetics; Insulin-Secreting Cells/cytology; Insulin-Secreting Cells/drug effects; Islets of Langerhans/cytology; Islets of Langerhans/drug effects; Islets of Langerhans/metabolism; Membrane Potential, Mitochondrial/drug effects; Mice; Mice, Knockout; Mice, Transgenic; Sarcoplasmic Reticulum Calcium-Transporting ATPases/antagonists & inhibitors; Sphingomyelin Phosphodiesterase/biosynthesis; Sphingomyelin Phosphodiesterase/genetics; Sphingomyelin Phosphodiesterase/metabolism; Tissue Culture Techniques; Unfolded Protein Response/drug effects

Key words

RIP-iPLA2ß-Tg; apoptosis; autophagy; caspase-3; iPLA2ß; iPLA2ß-KO; mitochondrial membrane potential; ß-cell

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Gene Expression Regulation, Enzymologic / Apoptosis / Insulin-Secreting Cells / Group IV Phospholipases A2 / Endoplasmic Reticulum Stress Type of study: Prognostic_studies Limits: Animals Language: En Journal: Islets Journal subject: ENDOCRINOLOGIA / GASTROENTEROLOGIA Year: 2013 Type: Article Affiliation country: United States

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