Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection.

Gomes, Marco Tulio R; Campos, Priscila C; Oliveira, Fernanda S; Corsetti, Patricia P; Bortoluci, Karina R; Cunha, Larissa D; Zamboni, Dario S; Oliveira, Sergio C

Gomes, Marco Tulio R; Campos, Priscila C; Oliveira, Fernanda S; Corsetti, Patricia P; Bortoluci, Karina R; Cunha, Larissa D; Zamboni, Dario S; Oliveira, Sergio C.

Affiliation

Gomes MT; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901 Brazil.

J Immunol ; 190(7): 3629-38, 2013 Apr 01.

Article in En | MEDLINE | ID: mdl-23460746

Subject(s)

Bacterial Secretion Systems; Brucella abortus/immunology; Brucella abortus/metabolism; Brucellosis/immunology; Brucellosis/metabolism; Caspase 1/metabolism; Cytoskeletal Proteins/metabolism; Inflammasomes; Animals; Apoptosis Regulatory Proteins/metabolism; CARD Signaling Adaptor Proteins; Calcium-Binding Proteins/metabolism; Carrier Proteins/genetics; Carrier Proteins/metabolism; Caspase 1/genetics; DNA, Bacterial/metabolism; DNA-Binding Proteins; Enzyme Activation; Genetic Predisposition to Disease; Granuloma/immunology; Granuloma/metabolism; Granuloma/microbiology; Immunity, Innate; Interleukin-18/genetics; Interleukin-18/metabolism; Interleukin-1beta/metabolism; Liver/pathology; Macrophages/immunology; Macrophages/metabolism; Mice; Mice, Knockout; Mitochondria/metabolism; Myeloid Differentiation Factor 88/metabolism; NLR Family, Pyrin Domain-Containing 3 Protein; Nuclear Proteins/genetics; Nuclear Proteins/metabolism; Reactive Oxygen Species/metabolism; Receptors, Interleukin-1/genetics; Receptors, Interleukin-1/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brucella abortus / Brucellosis / Caspase 1 / Cytoskeletal Proteins / Inflammasomes / Bacterial Secretion Systems Language: En Journal: J Immunol Year: 2013 Type: Article

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