DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism.

Zhang, Ling; Jiang, Meixiu; Shui, Yongsheng; Chen, Yuanli; Wang, Qixue; Hu, Wenquan; Ma, Xingzhe; Li, Xiaoju; Liu, Xin; Cao, Xingyue; Liu, Mengyang; Duan, Yajun; Han, Jihong

Zhang, Ling; Jiang, Meixiu; Shui, Yongsheng; Chen, Yuanli; Wang, Qixue; Hu, Wenquan; Ma, Xingzhe; Li, Xiaoju; Liu, Xin; Cao, Xingyue; Liu, Mengyang; Duan, Yajun; Han, Jihong.

Affiliation

Zhang L; Nankai University, Tianjin, China.

Biochim Biophys Acta ; 1831(6): 1134-45, 2013 Jun.

Article in En | MEDLINE | ID: mdl-23466610

Subject(s)

ATP-Binding Cassette Transporters/genetics; Cholesterol/metabolism; Foam Cells/drug effects; Gene Expression Regulation/drug effects; Macrophages/drug effects; Orphan Nuclear Receptors/metabolism; Topoisomerase II Inhibitors/pharmacology; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters/metabolism; Animals; Antineoplastic Agents, Phytogenic/pharmacology; Cells, Cultured; Electrophoretic Mobility Shift Assay; Etoposide/pharmacology; Fluorescent Antibody Technique; Foam Cells/cytology; Foam Cells/metabolism; Liver X Receptors; Macrophages/cytology; Macrophages/metabolism; Mice; Mice, Inbred C57BL; Orphan Nuclear Receptors/antagonists & inhibitors; Orphan Nuclear Receptors/genetics; Promoter Regions, Genetic/genetics; RNA, Small Interfering/genetics; Retinoid X Receptors/genetics; Retinoid X Receptors/metabolism; Teniposide/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / Cholesterol / ATP-Binding Cassette Transporters / Orphan Nuclear Receptors / Topoisomerase II Inhibitors / Foam Cells / Macrophages Limits: Animals Language: En Journal: Biochim Biophys Acta Year: 2013 Type: Article Affiliation country: China

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