Protection from articular damage by passive or active anti-tumour necrosis factor (TNF)-&#945; immunotherapy in human TNF-&#945; transgenic mice depends on anti-TNF-&#945; antibody levels.

Semerano, L; Biton, J; Delavallée, L; Duvallet, E; Assier, E; Bessis, N; Bernier, E; Dhellin, O; Grouard-Vogel, G; Boissier, M-C

Protection from articular damage by passive or active anti-tumour necrosis factor (TNF)-α immunotherapy in human TNF-α transgenic mice depends on anti-TNF-α antibody levels.

Semerano, L; Biton, J; Delavallée, L; Duvallet, E; Assier, E; Bessis, N; Bernier, E; Dhellin, O; Grouard-Vogel, G; Boissier, M-C.

Affiliation

Semerano L; Université Paris-13 Sorbonne Paris Cité, EA4222, Paris, France. luca.semerano@avc.aphp.fr

Clin Exp Immunol ; 172(1): 54-62, 2013 Apr.

Article in En | MEDLINE | ID: mdl-23480185

Subject(s)

Antibodies/immunology; Antirheumatic Agents/immunology; Arthritis, Rheumatoid/drug therapy; Cartilage, Articular/drug effects; Immunization, Passive; Immunotherapy, Active; Tumor Necrosis Factor-alpha/antagonists & inhibitors; Animals; Antibodies/administration & dosage; Antibodies/metabolism; Antibodies, Monoclonal/administration & dosage; Antibodies, Monoclonal/immunology; Antirheumatic Agents/administration & dosage; Antirheumatic Agents/metabolism; Arthritis, Rheumatoid/immunology; Arthritis, Rheumatoid/pathology; Cartilage, Articular/immunology; Cartilage, Articular/pathology; Drug Combinations; Infliximab; Male; Mice; Mice, Transgenic; ROC Curve; Tumor Necrosis Factor-alpha/administration & dosage; Tumor Necrosis Factor-alpha/immunology; Vaccination

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Cartilage, Articular / Immunotherapy, Active / Immunization, Passive / Tumor Necrosis Factor-alpha / Antirheumatic Agents / Antibodies Type of study: Prognostic_studies Limits: Animals Language: En Journal: Clin Exp Immunol Year: 2013 Type: Article Affiliation country: France

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