Nucleophosmin 1, upregulated in adenomas and cancers of the colon, inhibits p53-mediated cellular senescence.

Wong, John C T; Hasan, Mohammad R; Rahman, Mahbuba; Yu, Angel C; Chan, Simon K; Schaeffer, David F; Kennecke, Hagen F; Lim, Howard J; Owen, David; Tai, Isabella T

Wong, John C T; Hasan, Mohammad R; Rahman, Mahbuba; Yu, Angel C; Chan, Simon K; Schaeffer, David F; Kennecke, Hagen F; Lim, Howard J; Owen, David; Tai, Isabella T.

Affiliation

Wong JC; Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

Int J Cancer ; 133(7): 1567-77, 2013 Oct 01.

Article in En | MEDLINE | ID: mdl-23536448

Subject(s)

Adenoma/metabolism; Cell Survival/genetics; Cellular Senescence; Colorectal Neoplasms/metabolism; Nuclear Proteins/metabolism; Tumor Suppressor Protein p53/metabolism; Cell Cycle Checkpoints/genetics; Cell Line, Tumor; Gene Expression Profiling; Humans; Immunohistochemistry; Nuclear Proteins/genetics; Nucleophosmin; RNA Interference; RNA, Messenger/genetics; RNA, Messenger/metabolism; Tumor Suppressor Protein p53/antagonists & inhibitors; Tumor Suppressor Protein p53/genetics; Up-Regulation

Key words

adenoma; cellular senescence; colorectal cancer; nucleophosmin 1; p53

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Colorectal Neoplasms / Adenoma / Cell Survival / Tumor Suppressor Protein p53 / Cellular Senescence Type of study: Systematic_reviews Limits: Humans Language: En Journal: Int J Cancer Year: 2013 Type: Article Affiliation country: Canada

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