In vivo activity of human recombinant tissue inhibitor of metalloproteinases (TIMP). Activity against human stromelysin in vitro and in the rat pleural cavity.

Lark, M W; Saphos, C A; Walakovits, L A; Moore, V L

Lark, M W; Saphos, C A; Walakovits, L A; Moore, V L.

Affiliation

Lark MW; Department of Biochemical, Cellular, and Molecular Pathology, Merck Sharp & Dohme Research Laboratories, Rahway, NJ 07065.

Biochem Pharmacol ; 39(12): 2041-9, 1990 Jun 15.

Article in En | MEDLINE | ID: mdl-2353943

Subject(s)

Glycoproteins/pharmacology; Metalloendopeptidases/antagonists & inhibitors; Metalloendopeptidases/metabolism; Pleura/drug effects; Animals; Chromatography, Gel; Drug Interactions; Female; Humans; Matrix Metalloproteinase 3; Pleura/enzymology; Proteoglycans/metabolism; Rats; Recombinant Proteins/pharmacology; Tissue Inhibitor of Metalloproteinases; Transferrin/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Pleura / Metalloendopeptidases / Glycoproteins Limits: Animals / Female / Humans Language: En Journal: Biochem Pharmacol Year: 1990 Type: Article

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