Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling.

Morrison, Juliet; Laurent-Rolle, Maudry; Maestre, Ana M; Rajsbaum, Ricardo; Pisanelli, Giuseppe; Simon, Viviana; Mulder, Lubbertus C F; Fernandez-Sesma, Ana; García-Sastre, Adolfo

Morrison, Juliet; Laurent-Rolle, Maudry; Maestre, Ana M; Rajsbaum, Ricardo; Pisanelli, Giuseppe; Simon, Viviana; Mulder, Lubbertus C F; Fernandez-Sesma, Ana; García-Sastre, Adolfo.

Affiliation

Morrison J; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

PLoS Pathog ; 9(3): e1003265, 2013 Mar.

Article in En | MEDLINE | ID: mdl-23555265

Subject(s)

Calmodulin-Binding Proteins/metabolism; Cytoskeletal Proteins/metabolism; Dengue Virus/physiology; Interferon Type I/metabolism; STAT2 Transcription Factor/metabolism; Animals; Cell Line; Chlorocebus aethiops; Dengue Virus/pathogenicity; Humans; Immune Evasion; Protein Binding; Signal Transduction; Ubiquitin-Protein Ligases; Vero Cells; Viral Nonstructural Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calmodulin-Binding Proteins / Interferon Type I / Cytoskeletal Proteins / Dengue Virus / STAT2 Transcription Factor Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: PLoS Pathog Year: 2013 Type: Article Affiliation country: United States

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