Mast cells and fibroblasts work in concert to aggravate pulmonary fibrosis: role of transmembrane SCF and the PAR-2/PKC-&#945;/Raf-1/p44/42 signaling pathway.

Wygrecka, Malgorzata; Dahal, Bhola K; Kosanovic, Djuro; Petersen, Frank; Taborski, Brigitte; von Gerlach, Susanne; Didiasova, Miroslava; Zakrzewicz, Dariusz; Preissner, Klaus T; Schermuly, Ralph T; Markart, Philipp

Mast cells and fibroblasts work in concert to aggravate pulmonary fibrosis: role of transmembrane SCF and the PAR-2/PKC-α/Raf-1/p44/42 signaling pathway.

Wygrecka, Malgorzata; Dahal, Bhola K; Kosanovic, Djuro; Petersen, Frank; Taborski, Brigitte; von Gerlach, Susanne; Didiasova, Miroslava; Zakrzewicz, Dariusz; Preissner, Klaus T; Schermuly, Ralph T; Markart, Philipp.

Affiliation

Wygrecka M; Department of Biochemistry, Justus-Liebig-University Giessen, Universities Giessen, Giessen, Germany. malgorzata.wygrecka@innere.med.uni-giessen.de

Am J Pathol ; 182(6): 2094-108, 2013 Jun.

Article in En | MEDLINE | ID: mdl-23562441

Subject(s)

Fibroblasts/physiology; Mast Cells/physiology; Pulmonary Fibrosis/pathology; Cell Communication/physiology; Cell Count; Cell Degranulation/physiology; Cell Proliferation/drug effects; Cells, Cultured; Coculture Techniques; Dose-Response Relationship, Drug; Fibroblasts/drug effects; Fibroblasts/metabolism; Humans; Lung/metabolism; Lung/pathology; Mast Cells/metabolism; Protein Kinases/physiology; Pulmonary Fibrosis/metabolism; Receptor, PAR-2/physiology; Signal Transduction/drug effects; Signal Transduction/physiology; Stem Cell Factor/physiology; Tryptases/pharmacology; Tryptases/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Fibrosis / Fibroblasts / Mast Cells Limits: Humans Language: En Journal: Am J Pathol Year: 2013 Type: Article Affiliation country: Germany

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