Krüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young.

Lomberk, Gwen; Grzenda, Adrienne; Mathison, Angela; Escande, Carlos; Zhang, Jin-San; Calvo, Ezequiel; Miller, Laurence J; Iovanna, Juan; Chini, Eduardo N; Fernandez-Zapico, Martin E; Urrutia, Raul

Lomberk, Gwen; Grzenda, Adrienne; Mathison, Angela; Escande, Carlos; Zhang, Jin-San; Calvo, Ezequiel; Miller, Laurence J; Iovanna, Juan; Chini, Eduardo N; Fernandez-Zapico, Martin E; Urrutia, Raul.

Affiliation

Lomberk G; Laboratory of Epigenetics and Chromatin Dynamics, Epigenomics Translational Program, Mayo Clinic Center for Individualized Medicine, Division of Gastroenterology and Hepatology, and Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA.

J Biol Chem ; 288(24): 17745-58, 2013 Jun 14.

Article in En | MEDLINE | ID: mdl-23589285

Subject(s)

Cell Cycle Proteins/physiology; Diabetes Mellitus, Type 2/genetics; Gene Expression Regulation; Gene Regulatory Networks; Repressor Proteins/physiology; Amino Acid Sequence; Animals; Apoptosis Regulatory Proteins; CHO Cells; Cell Cycle Proteins/chemistry; Conserved Sequence; Cricetinae; Evolution, Molecular; GTP-Binding Protein beta Subunits/metabolism; Glucose/physiology; Humans; Insulin/genetics; Insulin/metabolism; Insulin Secretion; Molecular Sequence Data; Mutation, Missense; Promoter Regions, Genetic; Protein Binding; Protein Interaction Domains and Motifs; Rats; Repressor Proteins/chemistry; Signal Transduction; Transcription, Genetic; Two-Hybrid System Techniques

Key words

G Proteins; Gene Regulation; Gß2; KLF11; Krüppel-like Factor (KLF); Metabolic Gene Networks; Protein-Protein Interactions; Transcription; WD40

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Gene Expression Regulation / Cell Cycle Proteins / Diabetes Mellitus, Type 2 / Gene Regulatory Networks Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2013 Type: Article Affiliation country: United States

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