Discovery of potent transient receptor potential vanilloid 1 antagonists: design and synthesis of phenoxyacetamide derivatives.

Takahashi, Eiki; Hirano, Noriyuki; Nagahara, Takashi; Yoshikawa, Satoru; Momen, Shinobu; Yokokawa, Hiroshi; Hayashi, Ryoji

Takahashi, Eiki; Hirano, Noriyuki; Nagahara, Takashi; Yoshikawa, Satoru; Momen, Shinobu; Yokokawa, Hiroshi; Hayashi, Ryoji.

Affiliation

Takahashi E; Pharmaceutical Research Laboratories, Toray Industries, Inc., 10-1-6 Tebiro, Kamakura, Kanagawa 248-8555, Japan. eiki_takahashi@nts.toray.co.jp

Bioorg Med Chem Lett ; 23(11): 3154-6, 2013 Jun 01.

Article in En | MEDLINE | ID: mdl-23632270

Subject(s)

Acetamides/chemistry; Aminopyridines/chemistry; Drug Design; TRPV Cation Channels/antagonists & inhibitors; Acetamides/metabolism; Acetamides/therapeutic use; Aminopyridines/metabolism; Aminopyridines/therapeutic use; Animals; Capsaicin/toxicity; Cystitis/chemically induced; Cystitis/drug therapy; Drug Evaluation, Preclinical; Humans; Protein Binding; Rats; Structure-Activity Relationship; TRPV Cation Channels/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / TRPV Cation Channels / Aminopyridines / Acetamides Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Type: Article Affiliation country: Japan

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