Puerarin stimulates proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells via ER-dependent MEK/ERK and PI3K/Akt activation.

Wang, Yue; Wang, Wen Liang; Xie, Wen Li; Li, Ling Zhi; Sun, Jing; Sun, Wei Jia; Gong, Hai Ying

Wang, Yue; Wang, Wen Liang; Xie, Wen Li; Li, Ling Zhi; Sun, Jing; Sun, Wei Jia; Gong, Hai Ying.

Affiliation

Wang Y; Tianjin Key Laboratory for Prevention and Control of Occupational and Environmental Hazard, Tianjin, People's China. wy68wy68@yahoo.com.cn

Phytomedicine ; 20(10): 787-96, 2013 Jul 15.

Article in En | MEDLINE | ID: mdl-23639192

Subject(s)

Cell Differentiation/drug effects; Cell Proliferation/drug effects; Isoflavones/pharmacology; MAP Kinase Signaling System/drug effects; Osteoblasts/drug effects; Phosphatidylinositol 3-Kinases/drug effects; Proto-Oncogene Proteins c-akt/metabolism; Receptors, Estrogen/physiology; Alkaline Phosphatase/metabolism; Apoptosis/drug effects; Cell Line; Collagen/metabolism; Female; Humans; Isoflavones/therapeutic use; MAP Kinase Signaling System/physiology; Osteoblasts/enzymology; Phosphatidylinositol 3-Kinases/metabolism; Vasodilator Agents/pharmacology; Vasodilator Agents/therapeutic use

Key words

Differentiation; Osteoblast; Proliferation; Puerarin; Survival

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoblasts / Receptors, Estrogen / Cell Differentiation / Phosphatidylinositol 3-Kinases / MAP Kinase Signaling System / Cell Proliferation / Proto-Oncogene Proteins c-akt / Isoflavones Limits: Female / Humans Language: En Journal: Phytomedicine Journal subject: TERAPIAS COMPLEMENTARES Year: 2013 Type: Article

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