Gain-of-function mutations in transient receptor potential C6 (TRPC6) activate extracellular signal-regulated kinases 1/2 (ERK1/2).

Chiluiza, David; Krishna, Sneha; Schumacher, Valérie A; Schlöndorff, Johannes

Chiluiza, David; Krishna, Sneha; Schumacher, Valérie A; Schlöndorff, Johannes.

Affiliation

Chiluiza D; Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.

J Biol Chem ; 288(25): 18407-20, 2013 Jun 21.

Article in En | MEDLINE | ID: mdl-23645677

Subject(s)

Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Mutation; TRPC Cation Channels/physiology; Animals; Benzylamines/pharmacology; Calcineurin/metabolism; Calmodulin/metabolism; Cell Line; Enzyme Activation/drug effects; Enzyme Activation/physiology; Enzyme Inhibitors/pharmacology; ErbB Receptors/metabolism; Glomerulosclerosis, Focal Segmental/genetics; Glomerulosclerosis, Focal Segmental/metabolism; HEK293 Cells; Humans; Immunoblotting; Isoquinolines/pharmacology; Phosphorylation/drug effects; Podocytes/cytology; Podocytes/drug effects; Podocytes/metabolism; Signal Transduction/drug effects; Signal Transduction/physiology; Sulfonamides/pharmacology; TRPC Cation Channels/genetics; TRPC6 Cation Channel

Key words

Calcium; Epidermal Growth Factor Receptor (EGFR); Focal Segmental Glomerulosclerosis; Kidney; Protein Kinase A (PKA); TRP Channels

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mitogen-Activated Protein Kinase 1 / Mitogen-Activated Protein Kinase 3 / TRPC Cation Channels / Mutation Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2013 Type: Article Affiliation country: United States

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