Apolipoprotein A5 deficiency aggravates high-fat diet-induced obesity due to impaired central regulation of food intake.

van den Berg, Sjoerd A A; Heemskerk, Mattijs M; Geerling, Janine J; van Klinken, Jan-Bert; Schaap, Frank G; Bijland, Silvia; Berbée, Jimmy F P; van Harmelen, Vanessa J A; Pronk, Amanda C M; Schreurs, Marijke; Havekes, Louis M; Rensen, Patrick C N; van Dijk, Ko Willems

van den Berg, Sjoerd A A; Heemskerk, Mattijs M; Geerling, Janine J; van Klinken, Jan-Bert; Schaap, Frank G; Bijland, Silvia; Berbée, Jimmy F P; van Harmelen, Vanessa J A; Pronk, Amanda C M; Schreurs, Marijke; Havekes, Louis M; Rensen, Patrick C N; van Dijk, Ko Willems.

Affiliation

van den Berg SA; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

FASEB J ; 27(8): 3354-62, 2013 Aug.

Article in En | MEDLINE | ID: mdl-23650188

Subject(s)

Apolipoproteins/deficiency; Diet, High-Fat/adverse effects; Eating/physiology; Obesity/physiopathology; Animals; Apolipoprotein A-V; Apolipoproteins/administration & dosage; Apolipoproteins/genetics; Calorimetry; Eating/drug effects; Eating/genetics; Fatty Liver/genetics; Fatty Liver/metabolism; Hyperlipidemias/etiology; Hyperlipidemias/genetics; Hyperlipidemias/metabolism; Hyperphagia/etiology; Hyperphagia/genetics; Hyperphagia/metabolism; Injections, Intravenous; Injections, Intraventricular; Insulin Resistance/genetics; Insulin Resistance/physiology; Lipids/blood; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity/etiology; Obesity/genetics

Key words

APOA5; central nervous system; hyperphagia; triglyceride metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apolipoproteins / Eating / Diet, High-Fat / Obesity Type of study: Etiology_studies Limits: Animals Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2013 Type: Article Affiliation country: Netherlands

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