Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.

Kim, Myung H; Kang, Seung G; Park, Jeong H; Yanagisawa, Masashi; Kim, Chang H

Kim, Myung H; Kang, Seung G; Park, Jeong H; Yanagisawa, Masashi; Kim, Chang H.

Affiliation

Kim MH; Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, USA.

Gastroenterology ; 145(2): 396-406.e1-10, 2013 Aug.

Article in En | MEDLINE | ID: mdl-23665276

Subject(s)

Colitis/immunology; Epithelial Cells/immunology; Fatty Acids, Volatile/immunology; Intestinal Mucosa/cytology; MAP Kinase Signaling System/immunology; Receptors, G-Protein-Coupled/immunology; Animals; Citrobacter rodentium; Disease Models, Animal; Enterobacteriaceae Infections/immunology; Ethanol/immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, G-Protein-Coupled/genetics; Trinitrobenzenesulfonic Acid/immunology

Key words

2, 4, 6-trinitrobenzene sulfonic-acid; ATF2; C2; C3; C4; CFU; Colonic Inflammation; ECs; ERK; FITC; G-protein−coupled receptor; GPR; IL; Intestinal Barrier Leakage; KO; MAPK; Mouse Model; Pathogen; SCFAs; T-helper cell; TNBS; Th; WT; acetate; activating transcription factor 2; butyrate; colony-forming unit; epithelial cells; extracellular signal-regulated kinase; fluorescein isothiocyanate; interleukin; knock-out; mitogen-activated protein kinase; propionate; short-chain fatty acids; wild type

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colitis / MAP Kinase Signaling System / Receptors, G-Protein-Coupled / Epithelial Cells / Fatty Acids, Volatile / Intestinal Mucosa Type of study: Prognostic_studies Limits: Animals Language: En Journal: Gastroenterology Year: 2013 Type: Article Affiliation country: United States

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