Contribution of ADAMTS1 as a tumor suppressor gene in human breast carcinoma. Linking its tumor inhibitory properties to its proteolytic activity on nidogen-1 and nidogen-2.

Martino-Echarri, Estefanía; Fernández-Rodríguez, Rubén; Rodríguez-Baena, Francisco Javier; Barrientos-Durán, Antonio; Torres-Collado, Antoni X; Plaza-Calonge, María del Carmen; Amador-Cubero, Suyapa; Cortés, Javier; Reynolds, Louise E; Hodivala-Dilke, Kairbaan M; Rodríguez-Manzaneque, Juan Carlos

Martino-Echarri, Estefanía; Fernández-Rodríguez, Rubén; Rodríguez-Baena, Francisco Javier; Barrientos-Durán, Antonio; Torres-Collado, Antoni X; Plaza-Calonge, María del Carmen; Amador-Cubero, Suyapa; Cortés, Javier; Reynolds, Louise E; Hodivala-Dilke, Kairbaan M; Rodríguez-Manzaneque, Juan Carlos.

Affiliation

Martino-Echarri E; GENYO, Centre for Genomics and Oncological Research: Pfizer/Universidad de Granada/Junta de Andalucía, Granada, Spain.

Int J Cancer ; 133(10): 2315-24, 2013 Nov 15.

Article in En | MEDLINE | ID: mdl-23681936

Subject(s)

ADAM Proteins/metabolism; Breast Neoplasms/genetics; Cell Adhesion Molecules/metabolism; Genes, Tumor Suppressor; Membrane Glycoproteins/metabolism; Peptide Hydrolases/metabolism; ADAM Proteins/genetics; ADAMTS1 Protein; Animals; Basement Membrane/metabolism; Basement Membrane/pathology; Breast Neoplasms/blood supply; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Calcium-Binding Proteins; Cell Adhesion Molecules/genetics; Cell Line; Down-Regulation; Glycosaminoglycans/genetics; Glycosaminoglycans/metabolism; Glycosaminoglycans/physiology; HEK293 Cells; Humans; Membrane Glycoproteins/genetics; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic/genetics; Neovascularization, Pathologic/metabolism; Neovascularization, Pathologic/pathology; Proteolysis; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/metabolism

Key words

ADAMTS; breast carcinoma; extracellular proteolysis; nidogens; vascular basement membrane

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Hydrolases / Breast Neoplasms / Membrane Glycoproteins / Cell Adhesion Molecules / Genes, Tumor Suppressor / ADAM Proteins Limits: Animals / Humans Language: En Journal: Int J Cancer Year: 2013 Type: Article Affiliation country: Spain

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