AP-1B-mediated protein sorting regulates polarity and proliferation of intestinal epithelial cells in mice.

Hase, Koji; Nakatsu, Fubito; Ohmae, Masumi; Sugihara, Kazushi; Shioda, Noriko; Takahashi, Daisuke; Obata, Yuuki; Furusawa, Yukihiro; Fujimura, Yumiko; Yamashita, Taisuke; Fukuda, Shinji; Okamoto, Hiroshi; Asano, Masahide; Yonemura, Shigenobu; Ohno, Hiroshi

Hase, Koji; Nakatsu, Fubito; Ohmae, Masumi; Sugihara, Kazushi; Shioda, Noriko; Takahashi, Daisuke; Obata, Yuuki; Furusawa, Yukihiro; Fujimura, Yumiko; Yamashita, Taisuke; Fukuda, Shinji; Okamoto, Hiroshi; Asano, Masahide; Yonemura, Shigenobu; Ohno, Hiroshi.

Affiliation

Hase K; The University of Tokyo, Tokyo, Japan.

Gastroenterology ; 145(3): 625-35, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23684748

Subject(s)

Adaptor Protein Complex 1/deficiency; Adaptor Protein Complex mu Subunits/deficiency; Cell Polarity; Cell Proliferation; Epithelial Cells/metabolism; Intestinal Mucosa/metabolism; Intestine, Small/metabolism; Adaptor Protein Complex 1/physiology; Adaptor Protein Complex mu Subunits/physiology; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism; Biomarkers/metabolism; Cadherins/metabolism; Epithelial Cells/pathology; Epithelial Cells/physiology; Female; Fluorescent Antibody Technique; Intestinal Mucosa/pathology; Intestinal Mucosa/physiopathology; Intestine, Small/pathology; Intestine, Small/physiopathology; Male; Mice; Mice, 129 Strain; Mice, Knockout; Transcription Factor 4; beta Catenin/metabolism

Key words

AJ; AP; Apical and Basolateral; BMP; BrdU; Gene Regulation; LDLR; MDCK; MadinDarby canine kidney; TGF; TGN; Tight Junction; ZO-1; adaptor protein; adherens junction; bone morphogenic protein; bromodeoxyuridine; low-density lipoprotein receptor; trans-Golgi network; transforming growth factor; zonula occludens-1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Polarity / Adaptor Protein Complex 1 / Adaptor Protein Complex mu Subunits / Cell Proliferation / Epithelial Cells / Intestinal Mucosa / Intestine, Small Limits: Animals Language: En Journal: Gastroenterology Year: 2013 Type: Article Affiliation country: Japan

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