Changing associations between cognitive impairment and imaging in multiple sclerosis as the disease progresses.
J Neuropsychiatry Clin Neurosci
; 25(2): 134-40, 2013.
Article
in En
| MEDLINE
| ID: mdl-23686031
ABSTRACT
The authors explored cross-sectional associations between MRI parameters (lesion metrics, brain volumes, magnetization transfer ratio histograms, and metabolite concentrations) and cognition in 61 patients who experienced clinically-isolated syndromes (CIS) 7 years earlier. IQ decline and poorer overall cognition were associated with T2 white-matter lesions, and slow information-processing with both T2 lesions and gray-matter atrophy. In a previous study of the same cohort, gray-matter atrophy measured shortly after CIS failed to predict development of cognitive impairment years later. Our findings suggest that gray-matter pathology, reflected by atrophy measurements, becomes increasingly important in determining cognition as MS progresses.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Magnetic Resonance Imaging
/
Cognition Disorders
/
Disease Progression
/
Multiple Sclerosis
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Neuropsychiatry Clin Neurosci
Journal subject:
NEUROLOGIA
/
PSIQUIATRIA
Year:
2013
Type:
Article
Affiliation country:
United kingdom