Functional profiling of receptor tyrosine kinases and downstream signaling in human chondrosarcomas identifies pathways for rational targeted therapy.

Zhang, Yi-Xiang; van Oosterwijk, Jolieke G; Sicinska, Ewa; Moss, Samuel; Remillard, Stephen P; van Wezel, Tom; Bühnemann, Claudia; Hassan, Andrew B; Demetri, George D; Bovée, Judith V M G; Wagner, Andrew J

Zhang, Yi-Xiang; van Oosterwijk, Jolieke G; Sicinska, Ewa; Moss, Samuel; Remillard, Stephen P; van Wezel, Tom; Bühnemann, Claudia; Hassan, Andrew B; Demetri, George D; Bovée, Judith V M G; Wagner, Andrew J.

Affiliation

Zhang YX; Ludwig Center at Dana-Farber/Harvard and Center for Sarcoma and Bone Oncology, Department of Medical Oncology, Harvard Medical School, Boston, Massachusetts 02215, USA.

Clin Cancer Res ; 19(14): 3796-807, 2013 Jul 15.

Article in En | MEDLINE | ID: mdl-23714727

Subject(s)

Antineoplastic Agents/pharmacology; Bone Neoplasms/enzymology; Chondrosarcoma/enzymology; Imidazoles/pharmacology; Quinolines/pharmacology; Receptor Protein-Tyrosine Kinases/metabolism; Animals; Bone Neoplasms/drug therapy; Bone Neoplasms/genetics; Cell Line, Tumor; Chondrosarcoma/drug therapy; Chondrosarcoma/genetics; Enzyme Activation; Feedback, Physiological; Female; GTP Phosphohydrolases/genetics; Genetic Association Studies; Humans; Inhibitory Concentration 50; MAP Kinase Signaling System; Membrane Proteins/genetics; Mice; Mice, Nude; Molecular Targeted Therapy; Mutation, Missense; Phosphatidylinositol 3-Kinases/metabolism; Phosphorylation; Polymorphism, Single Nucleotide; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt/metabolism; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors; TOR Serine-Threonine Kinases/metabolism; Tissue Array Analysis; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Bone Neoplasms / Chondrosarcoma / Receptor Protein-Tyrosine Kinases / Imidazoles / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2013 Type: Article Affiliation country: United States

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