Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF.

Vandenbroucke, Roosmarijn E; Dejonckheere, Eline; Van Hauwermeiren, Filip; Lodens, Sofie; De Rycke, Riet; Van Wonterghem, Elien; Staes, An; Gevaert, Kris; López-Otin, Carlos; Libert, Claude

Vandenbroucke, Roosmarijn E; Dejonckheere, Eline; Van Hauwermeiren, Filip; Lodens, Sofie; De Rycke, Riet; Van Wonterghem, Elien; Staes, An; Gevaert, Kris; López-Otin, Carlos; Libert, Claude.

Affiliation

Vandenbroucke RE; Department for Molecular Biomedical Research, VIB, Ghent, Belgium.

EMBO Mol Med ; 5(7): 1000-16, 2013 Jul.

Article in En | MEDLINE | ID: mdl-23723167

Subject(s)

Inflammatory Bowel Diseases/immunology; Inflammatory Bowel Diseases/pathology; Intestinal Mucosa/pathology; Matrix Metalloproteinase 13/immunology; Sepsis/immunology; Sepsis/pathology; Animals; Colitis/chemically induced; Colitis/genetics; Colitis/immunology; Colitis/pathology; Dextran Sulfate; Endoplasmic Reticulum Stress; Female; Gene Deletion; Humans; Inflammatory Bowel Diseases/chemically induced; Inflammatory Bowel Diseases/genetics; Intestinal Mucosa/immunology; Intestinal Mucosa/metabolism; Lipopolysaccharides; Male; Matrix Metalloproteinase 13/genetics; Mice; Mice, Inbred C57BL; Permeability; Sepsis/chemically induced; Sepsis/genetics; Tight Junctions/immunology; Tight Junctions/pathology; Tumor Necrosis Factor-alpha/immunology

Key words

IBD; intestinal permeability; matrix metalloproteinase; sepsis; tumour necrosis factor

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammatory Bowel Diseases / Sepsis / Matrix Metalloproteinase 13 / Intestinal Mucosa Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: EMBO Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2013 Type: Article Affiliation country: Belgium

Fulltext

XML

PubMed Links

Search on Google