The minimum M3-M4 loop length of neurotransmitter-activated pentameric receptors is critical for the structural integrity of cytoplasmic portals.

Baptista-Hon, Daniel T; Deeb, Tarek Z; Lambert, Jeremy J; Peters, John A; Hales, Tim G

Baptista-Hon, Daniel T; Deeb, Tarek Z; Lambert, Jeremy J; Peters, John A; Hales, Tim G.

Affiliation

Baptista-Hon DT; Institute of Academic Anaesthesia, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom.

J Biol Chem ; 288(30): 21558-68, 2013 Jul 26.

Article in En | MEDLINE | ID: mdl-23740249

Subject(s)

Protein Conformation; Protein Structure, Secondary; Receptors, Serotonin, 5-HT3/chemistry; Receptors, Serotonin, 5-HT3/physiology; Amino Acid Sequence; Animals; Arginine/chemistry; Arginine/genetics; Arginine/physiology; Binding Sites/genetics; HEK293 Cells; Humans; Kinetics; Membrane Potentials/drug effects; Membrane Potentials/genetics; Membrane Potentials/physiology; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Patch-Clamp Techniques; Protein Multimerization; Receptors, Serotonin, 5-HT3/genetics; Sequence Homology, Amino Acid; Serotonin/pharmacology; Serotonin Receptor Agonists/pharmacology; Torpedo; Transfection

Key words

Cys-loop Receptors; GABA Receptors; Glycine Receptors; Ion Channels; Nicotinic Acetylcholine Receptors; Serotonin; Structural Biology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Conformation / Protein Structure, Secondary / Receptors, Serotonin, 5-HT3 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2013 Type: Article Affiliation country: United kingdom

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