Statins attenuate the development of atherosclerosis and endothelial dysfunction induced by exposure to urban particulate matter (PM10).

Miyata, Ryohei; Hiraiwa, Kunihiko; Cheng, Jui Chih; Bai, Ni; Vincent, Renaud; Francis, Gordon A; Sin, Don D; Van Eeden, Stephan F

Miyata, Ryohei; Hiraiwa, Kunihiko; Cheng, Jui Chih; Bai, Ni; Vincent, Renaud; Francis, Gordon A; Sin, Don D; Van Eeden, Stephan F.

Affiliation

Miyata R; UBC James Hogg Research Centre, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.

Toxicol Appl Pharmacol ; 272(1): 1-11, 2013 Oct 01.

Article in En | MEDLINE | ID: mdl-23756175

Subject(s)

Atherosclerosis/etiology; Atherosclerosis/prevention & control; Endothelium, Vascular; Environmental Exposure/adverse effects; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use; Lovastatin/therapeutic use; Particulate Matter/adverse effects; Vascular Diseases/etiology; Vascular Diseases/prevention & control; Animals; Blood Vessels/pathology; Cholesterol, Dietary/pharmacology; Cyclooxygenase 2/metabolism; Cytokines/biosynthesis; Endothelin-1/metabolism; Endothelins/blood; Immunohistochemistry; Lipids/blood; Male; Nitric Oxide Synthase Type II/metabolism; Plaque, Atherosclerotic/epidemiology; Plaque, Atherosclerotic/pathology; Rabbits; Reactive Oxygen Species; Urban Health

Key words

Atherosclerosis; COX-2; DIT; NT; PM; PM(10); Particulate matter; Reactive oxygen species; SNP; Statins; diffuse intimal thickening; iNOS; nitrotyrosine; particulate matter; particulate matter less than 10µm; sodium nitroprusside; the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vascular Diseases / Endothelium, Vascular / Lovastatin / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Environmental Exposure / Atherosclerosis / Particulate Matter Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Toxicol Appl Pharmacol Year: 2013 Type: Article Affiliation country: Canada

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