Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution.

Humphries, Adam; Cereser, Biancastella; Gay, Laura J; Miller, Daniel S J; Das, Bibek; Gutteridge, Alice; Elia, George; Nye, Emma; Jeffery, Rosemary; Poulsom, Richard; Novelli, Marco R; Rodriguez-Justo, Manuel; McDonald, Stuart A C; Wright, Nicholas A; Graham, Trevor A

Humphries, Adam; Cereser, Biancastella; Gay, Laura J; Miller, Daniel S J; Das, Bibek; Gutteridge, Alice; Elia, George; Nye, Emma; Jeffery, Rosemary; Poulsom, Richard; Novelli, Marco R; Rodriguez-Justo, Manuel; McDonald, Stuart A C; Wright, Nicholas A; Graham, Trevor A.

Affiliation

Humphries A; Histopathology Laboratory, Cancer Research UK London Research Institute, London, WC2A 3LY, United Kingdom.

Proc Natl Acad Sci U S A ; 110(27): E2490-9, 2013 Jul 02.

Article in En | MEDLINE | ID: mdl-23766371

Subject(s)

Adenoma/pathology; Cell Lineage/genetics; Colorectal Neoplasms/pathology; Multipotent Stem Cells/pathology; Neoplastic Stem Cells/pathology; Adenoma/genetics; Adenoma/metabolism; Cell Differentiation/genetics; Clone Cells/pathology; Colorectal Neoplasms/genetics; Colorectal Neoplasms/metabolism; DNA, Mitochondrial/genetics; DNA, Neoplasm/genetics; Epigenesis, Genetic; Humans; Models, Biological; Multipotent Stem Cells/metabolism; Mutation; Neoplastic Stem Cells/metabolism

Key words

cancer stem cells; intestinal adenomas; intratumor heterogeneity; tumor growth; tumor life-history

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Colorectal Neoplasms / Adenoma / Cell Lineage / Multipotent Stem Cells Type of study: Prognostic_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2013 Type: Article Affiliation country: United kingdom

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