Kupffer cells potentiate liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1.

Hutchins, Noelle A; Wang, Fei; Wang, Yvonne; Chung, Chun-Shiang; Ayala, Alfred

Hutchins, Noelle A; Wang, Fei; Wang, Yvonne; Chung, Chun-Shiang; Ayala, Alfred.

Affiliation

Hutchins NA; 1.Dept. of Surgery/Division of Surgical Research, 593 Eddy St., Aldrich Bldg., Room 227, Providence, RI 02903, USA. aayala@lifespan.org.

J Leukoc Biol ; 94(5): 963-70, 2013 Nov.

Article in En | MEDLINE | ID: mdl-23766529

Subject(s)

B7-H1 Antigen/physiology; Endothelial Cells/pathology; Kupffer Cells/physiology; Liver/pathology; Sepsis/pathology; Animals; Apoptosis; Capillary Permeability; Cell Proliferation; Liver/metabolism; Male; Mice; Mice, Inbred C57BL; STAT3 Transcription Factor/metabolism; fas Receptor/physiology

Key words

acute liver failure; coinhibitory molecules; hepatic endothelium; liver immune tolerance; septic inflammation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sepsis / Endothelial Cells / B7-H1 Antigen / Kupffer Cells / Liver Limits: Animals Language: En Journal: J Leukoc Biol Year: 2013 Type: Article Affiliation country: United States

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