Mitochondrial dysfunction represses HIF-1&#945; protein synthesis through AMPK activation in human hepatoma HepG2 cells.

Hsu, Chia-Chi; Wang, Chun-Hui; Wu, Ling-Chia; Hsia, Cheng-Yuan; Chi, Chin-Wen; Yin, Pen-Hui; Chang, Chun-Ju; Sung, Ming-Ta; Wei, Yau-Huei; Lu, Shing-Hwa; Lee, Hsin-Chen

Mitochondrial dysfunction represses HIF-1α protein synthesis through AMPK activation in human hepatoma HepG2 cells.

Hsu, Chia-Chi; Wang, Chun-Hui; Wu, Ling-Chia; Hsia, Cheng-Yuan; Chi, Chin-Wen; Yin, Pen-Hui; Chang, Chun-Ju; Sung, Ming-Ta; Wei, Yau-Huei; Lu, Shing-Hwa; Lee, Hsin-Chen.

Affiliation

Hsu CC; Department and Institute of Pharmacology, National Yang-Ming University, Taiwan.

Biochim Biophys Acta ; 1830(10): 4743-51, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23791554

Subject(s)

Adenylate Kinase/metabolism; Carcinoma, Hepatocellular/enzymology; Hypoxia-Inducible Factor 1, alpha Subunit/biosynthesis; Liver Neoplasms/enzymology; Mitochondria/physiology; Base Sequence; Carcinoma, Hepatocellular/pathology; DNA Primers; Enzyme Activation; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Liver Neoplasms/pathology; Real-Time Polymerase Chain Reaction

Key words

AMP-activated protein kinase; AMPK; Adenosine monophosphate-activated protein kinase; CAIX; CCCP; DMEM; Dulbecco's modified Eagle medium; HCC; HIF-1α; Hypoxia-inducible factor-1α; LDHA; Mitochondrial dysfunction; Protein synthesis; ROS; RT-PCR; carbonic anhydrase IX; carbonyl cyanide m-chlorophenyl hydrazine; hepatocellular carcinoma; hypoxia-inducible factor-1α; lactate dehydrogenase A; mitochondrial DNA; mtDNA; reactive oxygen species; reverse transcription-polymerase chain reaction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenylate Kinase / Carcinoma, Hepatocellular / Hypoxia-Inducible Factor 1, alpha Subunit / Liver Neoplasms / Mitochondria Limits: Humans Language: En Journal: Biochim Biophys Acta Year: 2013 Type: Article Affiliation country: Taiwan

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