Asperterrestide A, a cytotoxic cyclic tetrapeptide from the marine-derived fungus Aspergillus terreus SCSGAF0162.
J Nat Prod
; 76(6): 1182-6, 2013 Jun 28.
Article
in En
| MEDLINE
| ID: mdl-23806112
ABSTRACT
A new cytotoxic and antiviral cyclic tetrapeptide, asperterrestide A (1), a new alkaloid, terremide C (2), and a new aromatic butenolide, aspernolide E (3), together with 10 known compounds were isolated from the fermentation broth of the marine-derived fungus Aspergillus terreus SCSGAF0162. Their structures were elucidated by spectroscopic analysis, and the absolute configuration of 1 was determined by the Mosher ester technique and analysis of the acid hydrolysates using a chiral-phase HPLC column. Compound 1 contains a rare 3-OH-N-CH3-Phe residue and showed cytotoxicity against U937 and MOLT4 human carcinoma cell lines and inhibitory effects on influenza virus strains H1N1 and H3N2.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Peptides, Cyclic
/
Aspergillus
/
4-Butyrolactone
/
Alkaloids
/
Antineoplastic Agents
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
J Nat Prod
Year:
2013
Type:
Article