Identification of a suppressor mutation that improves the yields of hexon-modified adenovirus vectors.

Bruder, Joseph T; Chen, Ping; Semenova, Elena; Thomas, Charlie A; Konovalova, Svetlana; Ekberg, Greg; Ettyreddy, Damodar; McVey, Duncan; Gall, Jason G; King, C Richter; Brough, Douglas E

Bruder, Joseph T; Chen, Ping; Semenova, Elena; Thomas, Charlie A; Konovalova, Svetlana; Ekberg, Greg; Ettyreddy, Damodar; McVey, Duncan; Gall, Jason G; King, C Richter; Brough, Douglas E.

Affiliation

Bruder JT; GenVec, Inc, Gaithersburg, Maryland, USA. joetbruder@gmail.com

J Virol ; 87(17): 9661-71, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23824800

Subject(s)

Adenoviruses, Human/genetics; Capsid Proteins/genetics; Genetic Vectors; Adenoviruses, Human/immunology; Adenoviruses, Human/physiology; Amino Acid Sequence; Amino Acid Substitution; Animals; Antibodies, Neutralizing/immunology; Antibodies, Viral/immunology; Capsid Proteins/immunology; Cytokines/biosynthesis; Female; Genes, Viral; HEK293 Cells; Humans; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Sequence Homology, Amino Acid; Suppression, Genetic; Viral Vaccines/genetics; Viral Vaccines/immunology; Virus Replication/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenoviruses, Human / Capsid Proteins / Genetic Vectors Type of study: Diagnostic_studies Limits: Animals / Female / Humans Language: En Journal: J Virol Year: 2013 Type: Article Affiliation country: United States

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