HMG-CoA reductase inhibitors, simvastatin and atorvastatin, downregulate ABCG1-mediated cholesterol efflux in human macrophages.

Wang, Wei; Song, Wei; Wang, Yu; Chen, Lianfeng; Yan, Xiaowei

Wang, Wei; Song, Wei; Wang, Yu; Chen, Lianfeng; Yan, Xiaowei.

Affiliation

Wang W; Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

J Cardiovasc Pharmacol ; 62(1): 90-8, 2013 Jul.

Article in En | MEDLINE | ID: mdl-23846804

Subject(s)

ATP-Binding Cassette Transporters/antagonists & inhibitors; Cholesterol/metabolism; Heptanoic Acids/pharmacology; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology; Macrophages/metabolism; Pyrroles/pharmacology; Simvastatin/pharmacology; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters/physiology; Animals; Atorvastatin; Biotinylation; Blotting, Western; CHO Cells; Cell Separation; Cells, Cultured; Cricetinae; Cricetulus; Down-Regulation/drug effects; Humans; Hydrocarbons, Fluorinated/pharmacology; Indicators and Reagents; Lipoproteins, LDL/metabolism; Liver X Receptors; Macrophages/drug effects; Orphan Nuclear Receptors/agonists; Plasmids; Real-Time Polymerase Chain Reaction; Sulfonamides/pharmacology; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Cholesterol / ATP-Binding Cassette Transporters / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Simvastatin / Heptanoic Acids / Macrophages Limits: Animals / Humans Language: En Journal: J Cardiovasc Pharmacol Year: 2013 Type: Article Affiliation country: China

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