Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence.

Hampl, Veronika; Martin, Claudia; Aigner, Achim; Hoebel, Sabrina; Singer, Stephan; Frank, Natalie; Sarikas, Antonio; Ebert, Oliver; Prywes, Ron; Gudermann, Thomas; Muehlich, Susanne

Hampl, Veronika; Martin, Claudia; Aigner, Achim; Hoebel, Sabrina; Singer, Stephan; Frank, Natalie; Sarikas, Antonio; Ebert, Oliver; Prywes, Ron; Gudermann, Thomas; Muehlich, Susanne.

Affiliation

Hampl V; Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-University, Munich, Germany.

EMBO Mol Med ; 5(9): 1367-82, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23853104

Subject(s)

Carcinoma, Hepatocellular/physiopathology; Cell Proliferation; DNA-Binding Proteins/metabolism; Oncogene Proteins, Fusion/metabolism; Transcription Factors/metabolism; Aging; Animals; DNA-Binding Proteins/genetics; Gene Knockdown Techniques; Heterografts; Humans; Mice; Mice, Nude; Oncogene Proteins/metabolism; Oncogene Proteins, Fusion/genetics; Trans-Activators; Transcription Factors/genetics

Key words

DLC1; MKL1; MKL2; MRTF; senescence

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Oncogene Proteins, Fusion / Carcinoma, Hepatocellular / Cell Proliferation / DNA-Binding Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: EMBO Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2013 Type: Article Affiliation country: Germany

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