Characterization of the complex formed between a potent neutralizing ovine-derived polyclonal anti-TNF&#945; Fab fragment and human TNF&#945;.

Abbott, W Mark; Snow, Melanie; Eckersley, Sonia; Renshaw, Jonathan; Davies, Gareth; Norman, Richard A; Ceuppens, Peter; Slootstra, Jerry; Benschop, Joris J; Hamuro, Yoshitomo; Lee, Jessica E; Newham, Peter

Characterization of the complex formed between a potent neutralizing ovine-derived polyclonal anti-TNFα Fab fragment and human TNFα.

Abbott, W Mark; Snow, Melanie; Eckersley, Sonia; Renshaw, Jonathan; Davies, Gareth; Norman, Richard A; Ceuppens, Peter; Slootstra, Jerry; Benschop, Joris J; Hamuro, Yoshitomo; Lee, Jessica E; Newham, Peter.

Affiliation

Abbott WM; AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K. mark.abbott@astrazeneca.com

Biosci Rep ; 33(4)2013 Aug 23.

Article in En | MEDLINE | ID: mdl-23863106

Subject(s)

Immunoglobulin Fab Fragments/chemistry; Tumor Necrosis Factor-alpha/chemistry; Amino Acid Sequence; Amino Acid Substitution; Animals; Cell Line; Cell Survival/drug effects; Epitope Mapping; Epitopes/chemistry; Epitopes/immunology; Humans; Immunoglobulin Fab Fragments/pharmacology; Mice; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Protein Binding; Sheep, Domestic; Tumor Necrosis Factor-alpha/antagonists & inhibitors; Tumor Necrosis Factor-alpha/genetics; Tumor Necrosis Factor-alpha/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin Fab Fragments / Tumor Necrosis Factor-alpha Limits: Animals / Humans Language: En Journal: Biosci Rep Year: 2013 Type: Article Affiliation country: United kingdom

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