Nuclear factor &#954;B2 p52 protein has a role in antiviral immunity through I&#954;B kinase epsilon-dependent induction of Sp1 protein and interleukin 15.

Doyle, Sarah L; Shirey, Kari Ann; McGettrick, Anne F; Kenny, Elaine F; Carpenter, Susan; Caffrey, Brian E; Gargan, Siobhan; Quinn, Susan R; Caamaño, Jorge H; Moynagh, Paul; Vogel, Stefanie N; O'Neill, Luke A

Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15.

Doyle, Sarah L; Shirey, Kari Ann; McGettrick, Anne F; Kenny, Elaine F; Carpenter, Susan; Caffrey, Brian E; Gargan, Siobhan; Quinn, Susan R; Caamaño, Jorge H; Moynagh, Paul; Vogel, Stefanie N; O'Neill, Luke A.

Affiliation

Doyle SL; From the Immunology Research Centre, Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland,. Electronic address: Sarah.Doyle@tcd.ie.
Shirey KA; the Department of Microbiology and Immunology, University of Maryland, Baltimore, School of Medicine, Baltimore, Maryland 21201.
McGettrick AF; From the Immunology Research Centre, Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland.
Kenny EF; From the Immunology Research Centre, Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland.
Carpenter S; From the Immunology Research Centre, Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland.
Caffrey BE; the Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.
Gargan S; the Institute of Immunology, Department of Biology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland, and.
Quinn SR; From the Immunology Research Centre, Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland.
Caamaño JH; the Institute for BioMedical Research-Medical Research Council (IBR-MRC) Centre for Immune Regulation, College of Medicine and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.
Moynagh P; the Institute of Immunology, Department of Biology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland, and.
Vogel SN; the Department of Microbiology and Immunology, University of Maryland, Baltimore, School of Medicine, Baltimore, Maryland 21201.
O'Neill LA; From the Immunology Research Centre, Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland.

J Biol Chem ; 288(35): 25066-25075, 2013 Aug 30.

Article in En | MEDLINE | ID: mdl-23873932

Subject(s)

I-kappa B Kinase/immunology; Interleukin-15/metabolism; NF-kappa B p52 Subunit/immunology; Respiratory Syncytial Virus Infections/immunology; Respiratory Syncytial Viruses/immunology; Sp1 Transcription Factor/immunology; Animals; Gene Expression Regulation/drug effects; Gene Expression Regulation/genetics; Gene Expression Regulation/immunology; HEK293 Cells; Humans; I-kappa B Kinase/genetics; I-kappa B Kinase/metabolism; Interferon Inducers/pharmacology; Interleukin-15/genetics; Mice; Mice, Knockout; NF-kappa B p52 Subunit/genetics; NF-kappa B p52 Subunit/metabolism; Poly I-C/pharmacology; Respiratory Syncytial Virus Infections/genetics; Respiratory Syncytial Virus Infections/metabolism; Respiratory Syncytial Virus Infections/pathology; Respiratory Syncytial Viruses/genetics; Respiratory Syncytial Viruses/metabolism; Response Elements/genetics; Response Elements/immunology; Sp1 Transcription Factor/biosynthesis; Sp1 Transcription Factor/genetics; Toll-Like Receptor 3/genetics; Toll-Like Receptor 3/immunology; Toll-Like Receptor 3/metabolism; Transcription Factor RelA/genetics; Transcription Factor RelA/immunology; Transcription Factor RelA/metabolism

Key words

Cytokine Induction; Gene Regulation; Innate Immunity; Molecular Biology; NF-κB; Signal Transduction; Sp1; Toll-like Receptor (TLR); Transcription; Viral Immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory Syncytial Viruses / Sp1 Transcription Factor / Respiratory Syncytial Virus Infections / Interleukin-15 / I-kappa B Kinase / NF-kappa B p52 Subunit Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2013 Type: Article

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