Development of a human IgG4 bispecific antibody for dual targeting of interleukin-4 (IL-4) and interleukin-13 (IL-13) cytokines.

Spiess, Christoph; Bevers, Jack; Jackman, Janet; Chiang, Nancy; Nakamura, Gerald; Dillon, Michael; Liu, Hongbin; Molina, Patricia; Elliott, J Michael; Shatz, Whitney; Scheer, Justin M; Giese, Glen; Persson, Josefine; Zhang, Yin; Dennis, Mark S; Giulianotti, James; Gupta, Prateek; Reilly, Dorothea; Palma, Enzo; Wang, Jianyong; Stefanich, Eric; Scheerens, Heleen; Fuh, Germaine; Wu, Lawren C

Spiess, Christoph; Bevers, Jack; Jackman, Janet; Chiang, Nancy; Nakamura, Gerald; Dillon, Michael; Liu, Hongbin; Molina, Patricia; Elliott, J Michael; Shatz, Whitney; Scheer, Justin M; Giese, Glen; Persson, Josefine; Zhang, Yin; Dennis, Mark S; Giulianotti, James; Gupta, Prateek; Reilly, Dorothea; Palma, Enzo; Wang, Jianyong; Stefanich, Eric; Scheerens, Heleen; Fuh, Germaine; Wu, Lawren C.

Affiliation

Spiess C; From the Departments of Antibody Engineering.

J Biol Chem ; 288(37): 26583-93, 2013 Sep 13.

Article in En | MEDLINE | ID: mdl-23880771

Subject(s)

Antibodies, Bispecific/immunology; Gene Expression Regulation; Immunoglobulin G/immunology; Interleukin-13/metabolism; Interleukin-4/metabolism; Animals; Antibodies, Bispecific/biosynthesis; Antibodies, Monoclonal/immunology; Antibody Specificity; Cell Line, Tumor; Cell Proliferation; Female; Humans; Immunoglobulin G/biosynthesis; Lung/immunology; Lung/metabolism; Macaca fascicularis; Male; Mice; Mice, Inbred BALB C; Plasmids/metabolism; Protein Engineering/methods; Surface Plasmon Resonance

Key words

Antibody Engineering; Asthma; Cytokine; Immunoglobulin; Knobs-into-holes; Lebrikizumab; Lung; Protein Assembly

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Gene Expression Regulation / Interleukin-4 / Antibodies, Bispecific / Interleukin-13 Limits: Animals / Female / Humans / Male Language: En Journal: J Biol Chem Year: 2013 Type: Article

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