Active targeting of mesoporous silica drug carriers enhances Î³-secretase inhibitor efficacy in an in vivo model for breast cancer.

Wittig, Rainer; Rosenholm, Jessica M; von Haartman, Eva; Hemming, Jarl; Genze, Felicitas; Bergman, Lotta; Simmet, Thomas; Lindén, Mika; Sahlgren, Cecilia

Wittig, Rainer; Rosenholm, Jessica M; von Haartman, Eva; Hemming, Jarl; Genze, Felicitas; Bergman, Lotta; Simmet, Thomas; Lindén, Mika; Sahlgren, Cecilia.

Affiliation

Wittig R; Institute for Laser Technologies in Medicine & Metrology at Ulm University, Helmholtzstrasse 12, D-89081 Ulm, Germany.

Nanomedicine (Lond) ; 9(7): 971-87, 2014 May.

Article in En | MEDLINE | ID: mdl-23898823

Subject(s)

Amyloid Precursor Protein Secretases/antagonists & inhibitors; Breast Neoplasms/drug therapy; Drug Carriers/chemistry; Enzyme Inhibitors/therapeutic use; Nanoparticles/chemistry; Silicon Dioxide/chemistry; Triazines/therapeutic use; Animals; Enzyme Inhibitors/chemistry; Female; Humans; Mice; Mice, Nude; Porosity; Triazines/chemistry

Key words

Notch signaling; chorioallantoic membrane; folic acid receptor; mesoporous silica nanoparticle; targeted cancer therapy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triazines / Breast Neoplasms / Drug Carriers / Silicon Dioxide / Enzyme Inhibitors / Amyloid Precursor Protein Secretases / Nanoparticles Limits: Animals / Female / Humans Language: En Journal: Nanomedicine (Lond) Year: 2014 Type: Article Affiliation country: Germany

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