AIDS alters the commensal plasma virome.
J Virol
; 87(19): 10912-5, 2013 Oct.
Article
in En
| MEDLINE
| ID: mdl-23903845
ABSTRACT
We compared the plasma viromes of HIV-infected subjects with low versus high CD4(+) T cell counts from the United States and Uganda by using deep sequencing and detected HIV, hepatitis C virus, hepatitis B virus, GB virus C, anellovirus, and human endogenous retrovirus (HERV) reads. An increase in the proportion of reads for anelloviruses, a family of highly prevalent and genetically diverse human viruses, was seen in subjects with AIDS from both countries. The proportion of endogenous human retrovirus reads was increased in AIDS subjects from Uganda but not the United States. Progression to AIDS is therefore associated with changes in the plasma concentration of commensal viruses.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Virus Replication
/
Acquired Immunodeficiency Syndrome
/
HIV
/
Flaviviridae Infections
/
CD4 Lymphocyte Count
/
Hepatitis, Viral, Human
Type of study:
Prevalence_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Africa
/
America do norte
Language:
En
Journal:
J Virol
Year:
2013
Type:
Article
Affiliation country:
United States