The use of dornase alpha for post-operative pulmonary atelectasis after congenital heart surgery.
Cardiol Young
; 24(5): 807-12, 2014 Oct.
Article
in En
| MEDLINE
| ID: mdl-23915544
ABSTRACT
OBJECTIVE:
To investigate the efficacy of dornase alpha, a mucolytic agent, in children who developed pulmonary atelectasis after congenital heart surgery.DESIGN:
Retrospective case-control study.SETTING:
Paediatric cardiac intensive care unit at a tertiary care hospital. PATIENTS Between July, 2011 and July, 2012, 41 patients who underwent congenital cardiac operations and developed post-operative pulmonary atelectasis that was resistant to conventional treatment and chest physiotherapy.INTERVENTIONS:
In all, 26 patients received dornase alpha treatment. As a control group, 15 patients were treated with conventional medications and chest physiotherapy. MAINRESULTS:
The median age of patients was 25.5 (3-480) days in the study group and 50.0 (3-480) days in the control group. A total of 15 (57.6%) patients in the study group and 8 (53.3%) patients in the control group were male. The median weight was 4.2 (2.9-14.2) kg and 4.0 (3.5-13.6) kg in the study and control group, respectively. In the study group, pulmonary atelectasis was diagnosed at a median period of 5 (2-18) days after operations, whereas in the control group atelectasis was diagnosed at a median period of post-operative 6 (3-19) days. In the study group, the median atelectasis score decreased from 3.4 (1-6) to 0.8 (0-3) (p = 0.001). The median pO2 level increased from 69 (17-142) mmHg to 89 (30-168) mmHg (p = 0.04). In addition, heart rate and respiratory rate per minute were significantly decreased (p < 0.05). There were no significant changes in these parameters in the control group.CONCLUSIONS:
The use of dornase alpha can be effective for the management of pulmonary atelectasis that develops following congenital heart surgery.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pulmonary Atelectasis
/
Deoxyribonuclease I
/
Heart Defects, Congenital
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Cardiac Surgical Procedures
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Female
/
Humans
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Infant
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Male
/
Newborn
Language:
En
Journal:
Cardiol Young
Journal subject:
ANGIOLOGIA
/
CARDIOLOGIA
/
PEDIATRIA
Year:
2014
Type:
Article
Affiliation country:
Turkey