The neuroprotective activity of the amyloid precursor protein against traumatic brain injury is mediated via the heparin binding site in residues 96-110.

Corrigan, Frances; Thornton, Emma; Roisman, Laila C; Leonard, Anna V; Vink, Robert; Blumbergs, Peter C; van den Heuvel, Corinna; Cappai, Roberto

Corrigan, Frances; Thornton, Emma; Roisman, Laila C; Leonard, Anna V; Vink, Robert; Blumbergs, Peter C; van den Heuvel, Corinna; Cappai, Roberto.

Affiliation

Corrigan F; Discipline of Anatomy and Pathology, School of Medical Sciences, University of Adelaide, Adelaide, SA, Australia.

J Neurochem ; 128(1): 196-204, 2014 Jan.

Article in En | MEDLINE | ID: mdl-23919582

Subject(s)

Amyloid beta-Protein Precursor/metabolism; Brain Injuries/metabolism; Brain Injuries/prevention & control; Heparin/metabolism; Neuroprotective Agents/metabolism; Amino Acid Sequence; Amyloid beta-Protein Precursor/genetics; Amyloid beta-Protein Precursor/therapeutic use; Animals; Binding Sites/physiology; Heparin/chemistry; Heparin/genetics; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Neuroprotective Agents/therapeutic use; Protein Structure, Tertiary; Random Allocation; Rats; Rats, Sprague-Dawley

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Injuries / Heparin / Amyloid beta-Protein Precursor / Neuroprotective Agents Limits: Animals Language: En Journal: J Neurochem Year: 2014 Type: Article Affiliation country: Australia

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