Different types of aqueous two-phase systems for biomolecule and bioparticle extraction and purification.
Biotechnol Prog
; 29(6): 1343-53, 2013.
Article
in En
| MEDLINE
| ID: mdl-23925947
ABSTRACT
Upstream improvements have led to significant advances in the productivity of biomolecules and bioparticles. Today, downstream processes are the bottleneck in the production of some biopharmaceuticals, a change from previous years. Current purification platforms will reach their physical limits at some point, indicating the need for new approaches. This article reviews an alternative method to extract and purify biomolecules/bioparticles named aqueous two-phase system (ATPS). Biocompatibility and readiness to scale up are some of the ATPS characteristics. We also discuss some of ATPS applications in the biotechnology field.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biotechnology
/
Water
/
Proteins
Limits:
Humans
Language:
En
Journal:
Biotechnol Prog
Journal subject:
BIOTECNOLOGIA
Year:
2013
Type:
Article
Affiliation country:
Brazil