Systems biology of Ewing sarcoma: a network model of EWS-FLI1 effect on proliferation and apoptosis.

Stoll, Gautier; Surdez, Didier; Tirode, Franck; Laud, Karine; Barillot, Emmanuel; Zinovyev, Andrei; Delattre, Olivier

Stoll, Gautier; Surdez, Didier; Tirode, Franck; Laud, Karine; Barillot, Emmanuel; Zinovyev, Andrei; Delattre, Olivier.

Affiliation

Stoll G; Institut Curie, 26 rue d'Ulm, 75248 Paris cedex 05, France, INSERM U900, Bioinformatique, biostatistique et épidémiologie d'un système complexe, Paris, France, Mines ParisTech, Fontainebleau, France, INSERM U830, Unité de Génétique et Biologie des Cancers, Paris, France and Institut Curie, Unité de génétique somatique, Paris, France.

Nucleic Acids Res ; 41(19): 8853-71, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23935076

Subject(s)

Apoptosis/genetics; Bone Neoplasms/genetics; Cell Proliferation; Gene Regulatory Networks; Oncogene Proteins, Fusion/metabolism; Proto-Oncogene Protein c-fli-1/metabolism; RNA-Binding Protein EWS/metabolism; Sarcoma, Ewing/genetics; Bone Neoplasms/metabolism; Cell Line, Tumor; Data Mining; Gene Expression Regulation, Neoplastic; Humans; Models, Genetic; Oncogene Proteins, Fusion/antagonists & inhibitors; Oncogene Proteins, Fusion/genetics; Proto-Oncogene Protein c-fli-1/antagonists & inhibitors; Proto-Oncogene Protein c-fli-1/genetics; RNA, Small Interfering/metabolism; RNA-Binding Protein EWS/antagonists & inhibitors; RNA-Binding Protein EWS/genetics; Sarcoma, Ewing/metabolism; Signal Transduction; Systems Biology; Transcriptome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sarcoma, Ewing / Bone Neoplasms / Oncogene Proteins, Fusion / Apoptosis / RNA-Binding Protein EWS / Cell Proliferation / Proto-Oncogene Protein c-fli-1 / Gene Regulatory Networks Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nucleic Acids Res Year: 2013 Type: Article Affiliation country: France

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