Heat shock protein-27 attenuates foam cell formation and atherogenesis by down-regulating scavenger receptor-A expression via NF-&#954;B signaling.

Raizman, Joshua E; Chen, Yong-Xiang; Seibert, Tara; Hibbert, Benjamin; Cuerrier, Charles M; Salari, Samira; Zhao, Xiaoling; Hu, Tieqiang; Shi, Chunhua; Ma, Xiaoli; Simard, Trevor; Caravaggio, Justin; Rayner, Katey; Bowdish, Dawn; Moore, Kathryn; O'Brien, Edward R

Heat shock protein-27 attenuates foam cell formation and atherogenesis by down-regulating scavenger receptor-A expression via NF-κB signaling.

Raizman, Joshua E; Chen, Yong-Xiang; Seibert, Tara; Hibbert, Benjamin; Cuerrier, Charles M; Salari, Samira; Zhao, Xiaoling; Hu, Tieqiang; Shi, Chunhua; Ma, Xiaoli; Simard, Trevor; Caravaggio, Justin; Rayner, Katey; Bowdish, Dawn; Moore, Kathryn; O'Brien, Edward R.

Affiliation

Raizman JE; University of Ottawa Heart Institute, Ottawa, Canada.

Biochim Biophys Acta ; 1831(12): 1721-8, 2013 Dec.

Article in En | MEDLINE | ID: mdl-23939398

Subject(s)

Aorta/metabolism; Atherosclerosis/genetics; Foam Cells/metabolism; HSP27 Heat-Shock Proteins/genetics; NF-kappa B/genetics; Scavenger Receptors, Class A/genetics; Animals; Aorta/drug effects; Aorta/pathology; Apolipoproteins E/deficiency; Apolipoproteins E/genetics; Atherosclerosis/metabolism; Atherosclerosis/pathology; CHO Cells; Cell Line; Cricetulus; Diet, High-Fat; Disease Models, Animal; Female; Foam Cells/pathology; Gene Expression Regulation; HSP27 Heat-Shock Proteins/metabolism; Heat-Shock Proteins/pharmacology; Humans; Mice; Mice, Knockout; Molecular Chaperones; NF-kappa B/antagonists & inhibitors; NF-kappa B/metabolism; Neoplasm Proteins/pharmacology; Nitriles/pharmacology; Scavenger Receptors, Class A/antagonists & inhibitors; Scavenger Receptors, Class A/metabolism; Signal Transduction; Sulfones/pharmacology

Key words

Atherosclerosis; Heat shock protein 27; Macrophage; NF-κB; Scavenger receptor-A

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aorta / NF-kappa B / Atherosclerosis / Scavenger Receptors, Class A / HSP27 Heat-Shock Proteins / Foam Cells Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Biochim Biophys Acta Year: 2013 Type: Article Affiliation country: Canada

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