Activation of mTOR in the spinal cord is required for pain hypersensitivity induced by chronic constriction injury in mice.

Zhang, Wei; Sun, Xiao-Feng; Bo, Jin-Hua; Zhang, Juan; Liu, Xiao-Jie; Wu, Liu-Ping; Ma, Zheng-Liang; Gu, Xiao-Ping

Zhang, Wei; Sun, Xiao-Feng; Bo, Jin-Hua; Zhang, Juan; Liu, Xiao-Jie; Wu, Liu-Ping; Ma, Zheng-Liang; Gu, Xiao-Ping.

Affiliation

Zhang W; Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical Department of Nanjing University, Nanjing 210008, Jiangsu, People's Republic of China. Electronic address: genine@126.com.

Pharmacol Biochem Behav ; 111: 64-70, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23948070

Subject(s)

Pain Threshold/physiology; Spinal Cord Compression/physiopathology; Spinal Cord Injuries/physiopathology; TOR Serine-Threonine Kinases/physiology; Animals; Behavior, Animal; Chronic Disease; Male; Mice; Mice, Inbred C57BL; Sirolimus/pharmacology; Spinal Cord Compression/metabolism; Spinal Cord Injuries/metabolism

Key words

Neuropathic pain; Rapamycin; mTOR

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord Compression / Spinal Cord Injuries / Pain Threshold / TOR Serine-Threonine Kinases Type of study: Prognostic_studies Limits: Animals Language: En Journal: Pharmacol Biochem Behav Year: 2013 Type: Article

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